From the Natchez Trace Parkway (approximately 20 miles):  

Exit at the Tishomingo exit onto Hwy 25 NORTH.  Travel approximately 5 miles into downtown Tishomingo.  Go straight at the 4-way stop intersection.  Continue on Hwy 25 North and turn LEFT onto Hwy 30 West.  Travel approximately 2 miles.  Look for the green Crow's Neck Center sign.  You will cross under a rail road trestle and just before the Tenn-Tom waterway bridge, turn LEFT onto County Road 961.  Travel on CR 961 approximately two miles.  At the fork in the road, bear LEFT at the brown Crow's Neck Center sign.  Travel 2.5 miles to the Center.

From Hwy 45/Booneville (approximately 30 miles):

Traveling from the SOUTH or NORTH on Hwy 45, exit at the Booneville/30/4 exit.  Turn onto Hwy 30/4 EAST.  Travel on Hwy 30/4 East approximately 1 mile to a 4-way stop intersection.  Go straight, continuing on 30/4 East.  Travel approximately 2 miles to second 4-way stop intersection.  Turn LEFT on Hwy 30 EAST.  (Hwy 4 will go straight.)  Travel on Hwy 30 East, towards Paden/Iuka/Tishomingo approximately 18 miles.  (The road twists & turns and goes up hills & down dales.)  After immediately crossing the Tenn-Tom Waterway bridge, turn RIGHT on County Road 961 at the green Crow's Neck Center sign.  Travel on CR 961 approximately two miles.  At the fork in the road, bear LEFT at the brown Crow's Neck Center sign.  Travel 2.5 miles to the Center.

From Hwy 72/Iuka (approximately 20 miles):

Exit at the Iuka/Fulton exit and travel SOUTH on Hwy 25 to Hwy 30, approximately 15 miles.  Look for the green Crow’s Neck Center sign.  Turn RIGHT on Hwy 30 WEST.  Travel approximately 2 miles.  Look for the green Crow's Neck Center sign.  You will cross under a rail road trestle and just before the Tenn-Tom Waterway bridge, turn LEFT onto County Road 961.  Travel on CR 961 approximately two miles.  At the fork in the road, bear LEFT at the brown Crow’s Neck Center sign.  Travel 2.5 miles to the Center.